Hair

Spironolactone: the research history.

The HealthRX.com hair formula pairs oral minoxidil 1 mg with spironolactone 60 mg. Research on either ingredient alone addresses only part of the combination question.

7,392records matching the ingredient search
1connected formulations
8displayed publication records

How the research connects to the formula

The spironolactone search spans several medical subjects, while the product belongs to the hair catalog. Papers about another condition can explain an ingredient’s broader history without establishing a hair outcome.

A comparison of this formula with the minoxidil-finasteride oral formula changes the companion ingredient as well as its listed strength. It should therefore preserve the original trial population and the exact combination used.

Current HealthRX.com formulation map
ProductListed formulationConnected ingredient research
Minoxidil 1mg / Spironolactone 60mgMinoxidil 1mg / Spironolactone 60mgMinoxidil · Spironolactone

Publication history

When the ingredient appeared in the literature

The chart counts records mentioning the search terms in their title or abstract. It includes research beyond hair. Use the period controls to inspect the count.

2026: 260 indexed publications. 2026 includes publications dated through October 5. The earlier bars cover longer periods than the annual bars.

View the chart as a data table
PeriodPublications
1900-19590
1960-1969172
1970-1979592
1980-1989691
1990-1999638
2000-20091628
2010-2014916
2015-20191024
2020239
2021250
2022222
2023225
2024253
2025282
2026260
Search query and data source

Source: Europe PMC’s PubMed-indexed records. Retrieved October 5, 2026. The index’s firstPublicationDate field supplies the dates and chart periods; it can normalize a month-only record to the first day of the month. Dates through October 5 are included. Counts can change as the index adds or corrects records.

TITLE_ABS:(spironolactone) AND SRC:MED AND FIRST_PDATE:[1900-01-01 TO 2026-10-05]

Open this literature search · Download the data

A closer search for this product question

The focused search returns 79 publications. It narrows the ingredient query to terms connected with its catalog use. Its displayed records remain a search sample, not a ranking of study quality.

View the focused query

TITLE_ABS:(spironolactone) AND TITLE_ABS:(("female pattern hair" OR "androgenetic alopecia")) AND SRC:MED AND FIRST_PDATE:[1900-01-01 TO 2026-10-05]

Open the focused search

Dated publications

Read individual records in context

The timeline combines selected references with a sample from the ingredient search. Dates use the index’s firstPublicationDate field; the PubMed record may distinguish an earlier online date from the print date. Written study notes appear alongside the records that have them. Other entries show the indexed bibliography and link to the paper.

review-article · Review · Journal Article

Male and female pattern hair loss.

Iyengar L, Li J. Australian prescriber. PMID 40568688.

This record identifies a publication and its indexed publication types. The full paper contains the study methods, population, formulation and results.

Read the PubMed record · Publisher record

Questions that shape the comparison

Does the paper study a hair diagnosis, and is spironolactone given alone or with minoxidil? How long were participants observed?

Source records

Male and female pattern hair loss.Iyengar L, Li J.Australian prescriber. 2025-06-01. PMID 40568688. review-article, Review, Journal Article.
Androgenetic Alopecia in Women: A Narrative Review of Pathophysiology, Clinical Evaluation, and Treatments.Kearney CA, Brinks AL, Lawrence CN, Maas DE, Spindler AJ, Coric C, Gener-Pangilinan LA, Lasheras-Pérez MA, Shapiro J, Lo Sicco KI.American journal of clinical dermatology. 2026-02-19. PMID 41714473. Review, Journal Article.
Combination Therapy in Androgenetic Alopecia: A Network Meta-Analysis of Minoxidil and Other Pharmacological Agents.Bai Y, Ma X, Wei F, Li Y, Zhang X, Yang Y, Guo B.Aesthetic plastic surgery. 2026-05-21. PMID 42168420. Review, Network Meta-Analysis, Journal Article.
Sex-Specific Safety Signals of Finerenone Versus Spironolactone: Insights From the FDA Adverse Event Reporting System.Singla A, Singh G, Kaur G, Luthra S, Lodha C, Malik MS, Kalsoom S, Alo MS, Ali SS, Zulqarnain M.Cureus. 2026-07-25. PMID 42643702. research-article, Journal Article.
Evidence for the Use of Steroidal Aldosterone Antagonists in Patients With Kidney Failure.Georgianos PI, Kollias A, Roumeliotis A, Liakopoulos V.American journal of kidney diseases : the official journal of the National Kidney Foundation. 2026-08-14. PMID 42595037. Journal Article.
Isolated Lip Angioedema Associated With Spironolactone: A Case Report.Hosein T, Chang C, Nallamothu S, Maharaj ND.Cureus. 2026-08-28. PMID 42802754. Journal Article, Case Reports, case-report.
Biochemical characteristics associated with spironolactone use in hospitalized patients with hypotonic hyponatraemia.Klhůfek J, Vodička M, Fajkus M, Ryšavý I, Kojecký V, Šálek T.Annals of medicine. 2026-09-17. PMID 42752325. research-article, Journal Article.
Oral and Topical Spironolactone in Adult Female Acne: A Narrative Review Comparing Systemic and Local Approaches.Łyko M, Złotowska A, Jankowska-Konsur A.Clinical, cosmetic and investigational dermatology. 2026-09-26. PMID 42820094. review-article, Review, Journal Article.

Research data assembled by HealthRX.com from the displayed source records, October 5, 2026. The atlas contains a dated literature search and selected studies; it is not an exhaustive systematic review.