Skin

Zinc oxide: the research history.

Zinc oxide is listed at 5% in the salicylic-acid-niacinamide-urea cream. Its indexed literature includes material and formulation research as well as skin applications.

15,287records matching the ingredient search
1connected formulations
8displayed publication records

How the research connects to the formula

A zinc-oxide paper can concern a different particle preparation, concentration or vehicle. The ingredient name alone does not identify which of those properties matches the catalog cream.

The atlas connects zinc oxide with the other three ingredient histories. That map supports a formula comparison while keeping each study’s tested material and outcome available in its original record.

Current HealthRX.com formulation map
ProductListed formulationConnected ingredient research
Salicylic Acid / Zinc Oxide / Niacinamide / Ureasalicylic acid 2%, zinc oxide 5%, niacinamide 8% and urea 2%Salicylic acid · Zinc oxide · Niacinamide · Urea

Publication history

When the ingredient appeared in the literature

The chart counts records mentioning the search terms in their title or abstract. It includes research beyond skin. Use the period controls to inspect the count.

2026: 995 indexed publications. 2026 includes publications dated through October 5. The earlier bars cover longer periods than the annual bars.

View the chart as a data table
PeriodPublications
1900-195934
1960-196978
1970-1979189
1980-1989246
1990-1999365
2000-2009921
2010-20141879
2015-20193375
2020947
20211088
20221135
20231243
20241367
20251425
2026995
Search query and data source

Source: Europe PMC’s PubMed-indexed records. Retrieved October 5, 2026. The index’s firstPublicationDate field supplies the dates and chart periods; it can normalize a month-only record to the first day of the month. Dates through October 5 are included. Counts can change as the index adds or corrects records.

TITLE_ABS:("zinc oxide") AND SRC:MED AND FIRST_PDATE:[1900-01-01 TO 2026-10-05]

Open this literature search · Download the data

A closer search for this product question

The focused search returns 739 publications. It narrows the ingredient query to terms connected with its catalog use. Its displayed records remain a search sample, not a ranking of study quality.

View the focused query

TITLE_ABS:("zinc oxide") AND TITLE_ABS:((skin OR topical)) AND SRC:MED AND FIRST_PDATE:[1900-01-01 TO 2026-10-05]

Open the focused search

Dated publications

Read individual records in context

The timeline combines selected references with a sample from the ingredient search. Dates use the index’s firstPublicationDate field; the PubMed record may distinguish an earlier online date from the print date. Written study notes appear alongside the records that have them. Other entries show the indexed bibliography and link to the paper.

Journal Article

The role of biosynthesized zinc oxide nanoparticles in modulating the expression of virulence factors in multidrug-resistant Klebsiellapneumoniae.

Mahmood LJ, Ganjo AR, Ali FA. Microbial pathogenesis. PMID 42269978.

This record identifies a publication and its indexed publication types. The full paper contains the study methods, population, formulation and results.

Read the PubMed record · Publisher record

Questions that shape the comparison

Does the source describe the zinc-oxide preparation? Is the endpoint a material property or a measured skin outcome in people?

Source records

Multiphoton Tomography of Micro- and Nanocosmetics in Human Skin: In vivo Studies in Volunteers and Patients with ex vivo Validation.Henriques Ribeiro Machado AC, Mohammed Y, Roberts MS, Leite-Silva VR.Skin pharmacology and physiology. 2026-06-25. PMID 42348512. Review, Journal Article.
Comparison of penetration depth into dentinal tubules and push-out bond strength of zinc oxide and copper doped zinc oxide nanoparticles sealers : an in-vitro study.Mollashahi NF, Saberi E, Tabatabaei AM, Radfar S.BMC oral health. 2026-06-27. PMID 42365261. Comparative Study, research-article, Journal Article.
Correction: Enhanced accumulation of phenolics in pea (<i>Pisum sativum</i> L.) seeds upon foliar application of selenate or zinc oxide.Malka M, Du Laing G, Kurešová G, Hegedüsová A, Bohn T.Frontiers in nutrition. 2026-07-10. PMID 42500244. Published Erratum, correction.
Effectiveness of Structured Skin Care Using Silicone Barrier Spray Compared with Zinc Oxide Ointment for Incontinence-Associated Dermatitis in Long-Term Care Residents: A Randomized Controlled Trial.Chen PC, Chu CM, Hsiao PJ, Tsai HC.International journal of medical sciences. 2026-08-24. PMID 42807271. Comparative Study, research-article, Randomized Controlled Trial, Journal Article.
Topical maternal breast milk versus commercial topical products for diaper dermatitis in infants: a systematic review.Qandeel RNJ, Woei Ling T, Chong MC, Ayed AJ.Journal of research in nursing : JRN. 2026-09-28. PMID 42812452. Review, Journal Article.
Synthesis and characterization of sustainable Zinc Oxide nanoparticles for waxy crude flow assurance application.Aji A, Ben Mahmud HK, Abduljabbar A, Hussein IA, Malek NANN, Ola VD, Mohyaldinn ME.PloS one. 2026-09-28. PMID 42804490. research-article, Journal Article.

Research data assembled by HealthRX.com from the displayed source records, October 5, 2026. The atlas contains a dated literature search and selected studies; it is not an exhaustive systematic review.