Enclomiphene: Research History & Formulation Comparisons

How the research connects to the formula

The displayed 2015 paper describes two randomized studies comparing enclomiphene with topical testosterone gel in overweight men with secondary hypogonadism. It measured testosterone, LH, FSH and sperm concentration over sixteen weeks.

This comparison provides a more specific research question than grouping every hormone-related product together. It also retains the testosterone preparation used in the trials, rather than treating every cream and injection as the same comparator.

Current HealthRX.com formulation map
Product	Listed formulation	Connected ingredient research
Enclomiphene	Enclomiphene 6.25 / 12.5 / 25 mg	Enclomiphene

Publication history

When the ingredient appeared in the literature

The chart counts records mentioning the search terms in their title or abstract. It includes research beyond hormones. Use the period controls to inspect the count.

2026: 4 indexed publications. 2026 includes publications dated through October 5. The earlier bars cover longer periods than the annual bars.

View the chart as a data table

Period	Publications
1900-1959	0
1960-1969	0
1970-1979	1
1980-1989	24
1990-1999	13
2000-2009	11
2010-2014	3
2015-2019	11
2020	1
2021	1
2022	1
2023	2
2024	1
2025	5
2026	4

Search query and data source

Source: Europe PMC’s PubMed-indexed records. Retrieved October 5, 2026. The index’s firstPublicationDate field supplies the dates and chart periods; it can normalize a month-only record to the first day of the month. Dates through October 5 are included. Counts can change as the index adds or corrects records.

TITLE_ABS:(enclomiphene) AND SRC:MED AND FIRST_PDATE:[1900-01-01 TO 2026-10-05]

Open this literature search · Download the data

Dated publications

Read individual records in context

The timeline combines selected references with a sample from the ingredient search. Dates use the index’s firstPublicationDate field; the PubMed record may distinguish an earlier online date from the print date. Written study notes appear alongside the records that have them. Other entries show the indexed bibliography and link to the paper.

Clinical Trial, Phase III · Multicenter Study · Randomized Controlled Trial · Journal Article

Oral enclomiphene citrate raises testosterone and preserves sperm counts in obese hypogonadal men, unlike topical testosterone: restoration instead of replacement.

Kim ED, McCullough A, Kaminetsky J. BJU international. PMID 26496621.

Study design: Two randomized, double-blind, double-dummy phase 3 studies
What was tested: Oral enclomiphene versus topical testosterone gel in overweight men aged 18 to 60 with secondary hypogonadism, over 16 weeks.
What was reported: Testosterone increased in the treatment groups. LH and FSH patterns and sperm-concentration results differed between enclomiphene and testosterone gel.
How it connects to the catalog: The comparator was testosterone gel. A cream or injection product should retain its different preparation when this comparison is described.

Read the PubMed record · Publisher record

Study comparison

Publication	Design and regimen	Reported finding	Interpretation
2015-10-23: Oral enclomiphene citrate raises testosterone and preserves sperm counts in obese hypogonadal men, unlike topical testosterone: restoration instead of replacement.	Two randomized, double-blind, double-dummy phase 3 studies. Oral enclomiphene versus topical testosterone gel in overweight men aged 18 to 60 with secondary hypogonadism, over 16 weeks.	Testosterone increased in the treatment groups. LH and FSH patterns and sperm-concentration results differed between enclomiphene and testosterone gel.	The comparator was testosterone gel. A cream or injection product should retain its different preparation when this comparison is described.

Questions that shape the comparison

Does the study population have the same type of hypogonadism? Which hormone, sperm and symptom outcomes were measured?

Source records

Oral enclomiphene citrate raises testosterone and preserves sperm counts in obese hypogonadal men, unlike topical testosterone: restoration instead of replacement.Kim ED, McCullough A, Kaminetsky J.BJU international. 2015-10-23. PMID 26496621. Clinical Trial, Phase III, Multicenter Study, Randomized Controlled Trial, Journal Article.

Response to the letter to the editor: Clomiphene or enclomiphene citrate for the treatment of male hypogonadism: a systematic review and meta-analysis of randomized controlled trials.Hohl A, Chavez MP, Pasqualotto E, Ferreira ROM, Sande-Lee SV, Ronsoni MF.Archives of endocrinology and metabolism. 2025-11-28. PMID 41312855. Letter, review-article.

Comment on Clomiphene or enclomiphene citrate for the treatment of male hypogonadism: a systematic review and meta-analysis of randomized controlled trials.Peng B.Archives of endocrinology and metabolism. 2025-11-28. PMID 41312854. Letter, review-article.

British Society of Sexual Medicine: Position Statement for the Potential Use of Enclomiphene in the Treatment of Male Hypogonadism.Foster J, Choo L, Patel A, Kirby M, Hackett G.The world journal of men's health. 2026-02-13. PMID 41714894. Editorial.

Changes in Serum Testosterone After Sublingual Enclomiphene Citrate Combined With a Mineral Oxide Delivery System: A Retrospective Case Series of 15 Men.Warren S.Cureus. 2026-05-20. PMID 42170362. research-article, Journal Article.

Newly Detected Atrial Flutter After Enclomiphene Dose Escalation in a Patient With Prior Mitral Valve Repair and Chronic Immune Thrombocytopenia: A Case Report.Tariq MN, Abdel Halim AT, Evans JA.Cureus. 2026-08-15. PMID 42741668. Journal Article, Case Reports, case-report.

Research data assembled by HealthRX.com from the displayed source records, October 5, 2026. The atlas contains a dated literature search and selected studies; it is not an exhaustive systematic review.