Kojic acid appears in the hydroquinone-niacinamide combination. The ingredient’s laboratory literature and human pigmentation research address different steps in the formulation question.
1,502records matching the ingredient search
1connected formulations
9displayed publication records
How the research connects to the formula
The catalog lists kojic acid 6%, hydroquinone 6% and niacinamide 5%. A paper about kojic acid alone or another combination can be related to that formula while keeping the tested material separate.
The displayed 2013 study examined skin-lightening ingredients in cells. Its findings concern cellular experiments, not a measured cosmetic response to this cream in people.
The chart counts records mentioning the search terms in their title or abstract. It includes research beyond skin. Use the period controls to inspect the count.
2026: 80 indexed publications. 2026 includes publications dated through October 5. The earlier bars cover longer periods than the annual bars.
View the chart as a data table
Period
Publications
1900-1959
24
1960-1969
6
1970-1979
15
1980-1989
19
1990-1999
58
2000-2009
200
2010-2014
236
2015-2019
264
2020
85
2021
78
2022
119
2023
94
2024
113
2025
111
2026
80
Search query and data source
Source: Europe PMC’s PubMed-indexed records. Retrieved October 5, 2026. The index’s firstPublicationDate field supplies the dates and chart periods; it can normalize a month-only record to the first day of the month. Dates through October 5 are included. Counts can change as the index adds or corrects records.
TITLE_ABS:("kojic acid") AND SRC:MED AND FIRST_PDATE:[1900-01-01 TO 2026-10-05]
The focused search returns 166 publications. It narrows the ingredient query to terms connected with its catalog use. Its displayed records remain a search sample, not a ranking of study quality.
View the focused query
TITLE_ABS:("kojic acid") AND TITLE_ABS:((melasma OR pigmentation)) AND SRC:MED AND FIRST_PDATE:[1900-01-01 TO 2026-10-05]
The timeline combines selected references with a sample from the ingredient search. Dates use the index’s firstPublicationDate field; the PubMed record may distinguish an earlier online date from the print date. Written study notes appear alongside the records that have them. Other entries show the indexed bibliography and link to the paper.
research-article · Journal Article
Examining the impact of skin lighteners in vitro.
Gruber JV, Holtz R. Oxidative medicine and cellular longevity. PMID 23738040.
Study design
Cell-based laboratory research
What was tested
Hydroquinone, kojic acid and niacinamide in pigmentation-related experiments.
What was reported
The experiments examined cellular effects of the studied ingredients.
How it connects to the catalog
Cell experiments can address mechanisms. They do not measure the visible effect of HealthRX.com’s topical combination in people.
Research data assembled by HealthRX.com from the displayed source records, October 5, 2026. The atlas contains a dated literature search and selected studies; it is not an exhaustive systematic review.