Sexual health

Oxytocin: the research history.

Oxytocin connects a single-ingredient nasal spray with a three-ingredient nasal blend. Both use a nasal format, while their ingredient lists and listed concentrations differ.

28,016records matching the ingredient search

2connected formulations

6displayed publication records

How the research connects to the formula

The 2015 randomized crossover study tested intranasal oxytocin in thirty women with sexual dysfunction. Both oxytocin and placebo groups improved over time, without a statistically significant treatment effect. That finding belongs in the comparison alongside the product’s ingredient identity.

The single-ingredient product lists oxytocin 100 IU/mL. The blend lists oxytocin 600 IU/mL alongside tadalafil and bremelanotide. A concentration is not the administered quantity; the study dose and delivered volume are separate fields.

Current HealthRX.com formulation map
Product	Listed formulation	Connected ingredient research
Oxytocin Nasal Spray	Oxytocin 100 IU/mL	Oxytocin
Tadalafil / Oxytocin / PT-141 Nasal Spray	Tadalafil 50 mg/mL / Oxytocin 600 IU/mL / PT-141 2.5 mg/mL	Tadalafil · Oxytocin · Bremelanotide / PT-141

Publication history

When the ingredient appeared in the literature

The chart counts records mentioning the search terms in their title or abstract. It includes research beyond sexual health. Use the period controls to inspect the count.

2026: 752 indexed publications. 2026 includes publications dated through October 5. The earlier bars cover longer periods than the annual bars.

View the chart as a data table

Period	Publications
1900-1959	269
1960-1969	997
1970-1979	1728
1980-1989	3294
1990-1999	4479
2000-2009	4073
2010-2014	2965
2015-2019	4030
2020	894
2021	953
2022	904
2023	852
2024	846
2025	980
2026	752

Search query and data source

Source: Europe PMC’s PubMed-indexed records. Retrieved October 5, 2026. The index’s firstPublicationDate field supplies the dates and chart periods; it can normalize a month-only record to the first day of the month. Dates through October 5 are included. Counts can change as the index adds or corrects records.

TITLE_ABS:(oxytocin) AND SRC:MED AND FIRST_PDATE:[1900-01-01 TO 2026-10-05]

Open this literature search · Download the data

Dated publications

Read individual records in context

The timeline combines selected references with a sample from the ingredient search. Dates use the index’s firstPublicationDate field; the PubMed record may distinguish an earlier online date from the print date. Written study notes appear alongside the records that have them. Other entries show the indexed bibliography and link to the paper.

Research Support, Non-U.S. Gov't · Randomized Controlled Trial · Journal Article

Effect of long-term intranasal oxytocin on sexual dysfunction in premenopausal and postmenopausal women: a randomized trial.

Muin DA, Wolzt M, Marculescu R, Sheikh Rezaei S, Salama M, Fuchs C, Luger A, Bragagna E, Litschauer B, Bayerle-Eder M. Fertility and sterility. PMID 26151620.

Study design: Randomized crossover study, 30 women with sexual dysfunction
What was tested: Intranasal oxytocin 32 IU or placebo over eight weeks, followed by crossover after a washout.
What was reported: Both oxytocin and placebo groups improved; there was no statistically significant treatment effect.
How it connects to the catalog: The study needs to be read as intranasal oxytocin research. It does not establish a result for a nasal blend containing tadalafil and bremelanotide.

Read the PubMed record · Publisher record

Study comparison

Publication	Design and regimen	Reported finding	Interpretation
2015-07-04: Effect of long-term intranasal oxytocin on sexual dysfunction in premenopausal and postmenopausal women: a randomized trial.	Randomized crossover study, 30 women with sexual dysfunction. Intranasal oxytocin 32 IU or placebo over eight weeks, followed by crossover after a washout.	Both oxytocin and placebo groups improved; there was no statistically significant treatment effect.	The study needs to be read as intranasal oxytocin research. It does not establish a result for a nasal blend containing tadalafil and bremelanotide.

Questions that shape the comparison

Was the study about sexual function, desire, social behavior or another endpoint? Did it show a treatment difference from placebo?

Source records

Effect of long-term intranasal oxytocin on sexual dysfunction in premenopausal and postmenopausal women: a randomized trial.Muin DA, Wolzt M, Marculescu R, Sheikh Rezaei S, Salama M, Fuchs C, Luger A, Bragagna E, Litschauer B, Bayerle-Eder M.Fertility and sterility. 2015-07-04. PMID 26151620. Research Support, Non-U.S. Gov't, Randomized Controlled Trial, Journal Article.

Gene-environment interaction between perinatal oxytocin exposure and Pten mutation shapes epigenetic reprogramming of oxytocin signaling and behavior in mice.Bussies PL, Tan Z, Shelestak J, Sarn N, Lee JH, Sadler T, Eng C, Louveau A, DeSilva TM.Neurobiology of disease. 2026-08-04. PMID 42551658. Journal Article.

Comparative atlas of PVN oxytocin and vasopressin systems reveals sex-conserved input-output wiring.Freda SN, Lowe YF, Priest MF, Badong D, Liu Y, Xiao L, Kozorovitskiy Y.Proceedings of the National Academy of Sciences of the United States of America. 2026-09-01. PMID 42679028. Comparative Study, Journal Article.

Oxytocin Variants Induce Cellular Signaling and Neurite Outgrowth in Human-Derived Neuron-like SH-SY5Y Cell Line.Vattem N, Snyder M, Leschinsky A, Aziz A, Amin J, Butt M, Aburas J, Pierce ML.NeuroSci. 2026-09-03. PMID 42776672. research-article, Journal Article.

Higher maternal body mass index is associated with increased oxytocin requirements during induction of labor: a population-based cohort study.Bladfält N, Isgren AR, Blomberg M, Carlhäll S.American journal of obstetrics & gynecology MFM. 2026-09-07. PMID 42705385. Journal Article.

A multiscale PBPK-PD model of oxytocin-induced uterine excitation and contraction.Yang Y, Bradley C, Zhang X, Clark A, Gao M, Li G, Yang L, Monfort-Ortiz R, Meng Y, Hao D, Ye-Lin Y.The Journal of physiology. 2026-09-11. PMID 42725451. research-article, Journal Article.

Research data assembled by HealthRX.com from the displayed source records, October 5, 2026. The atlas contains a dated literature search and selected studies; it is not an exhaustive systematic review.