Sexual health

Tadalafil: the research history.

Tadalafil appears as an as-needed tablet, a daily tablet, a component of TEMPO, and a component of a nasal blend. The administration schedule is part of the research question.

2,918records matching the ingredient search
4connected formulations
7displayed publication records

How the research connects to the formula

The tablet listings distinguish 10 mg and 20 mg options from daily 2.5 mg and 5 mg options. TEMPO adds other ingredients and a sublingual format. The nasal product combines tadalafil with oxytocin and bremelanotide.

This map makes comparisons more precise: an ingredient-level paper can be connected to several products while keeping each product’s route and companions visible. Research on a daily oral regimen should retain that schedule when it is described.

Current HealthRX.com formulation map
ProductListed formulationConnected ingredient research
TEMPO 4-in-1Apomorphine / Sildenafil / Tadalafil / VardenafilApomorphine · Sildenafil · Tadalafil · Vardenafil
Tadalafil10mg / 20mgTadalafil
Tadalafil Daily2.5mg / 5mgTadalafil
Tadalafil / Oxytocin / PT-141 Nasal SprayTadalafil 50 mg/mL / Oxytocin 600 IU/mL / PT-141 2.5 mg/mLTadalafil · Oxytocin · Bremelanotide / PT-141

Publication history

When the ingredient appeared in the literature

The chart counts records mentioning the search terms in their title or abstract. It includes research beyond sexual health. Use the period controls to inspect the count.

2026: 106 indexed publications. 2026 includes publications dated through October 5. The earlier bars cover longer periods than the annual bars.

View the chart as a data table
PeriodPublications
1900-19590
1960-19690
1970-19790
1980-19890
1990-19990
2000-2009623
2010-2014631
2015-2019660
2020150
2021141
2022161
2023146
2024140
2025160
2026106
Search query and data source

Source: Europe PMC’s PubMed-indexed records. Retrieved October 5, 2026. The index’s firstPublicationDate field supplies the dates and chart periods; it can normalize a month-only record to the first day of the month. Dates through October 5 are included. Counts can change as the index adds or corrects records.

TITLE_ABS:(tadalafil) AND SRC:MED AND FIRST_PDATE:[1900-01-01 TO 2026-10-05]

Open this literature search · Download the data

A closer search for this product question

The focused search returns 1,185 publications. It narrows the ingredient query to terms connected with its catalog use. Its displayed records remain a search sample, not a ranking of study quality.

View the focused query

TITLE_ABS:(tadalafil) AND TITLE_ABS:("erectile dysfunction") AND SRC:MED AND FIRST_PDATE:[1900-01-01 TO 2026-10-05]

Open the focused search

Dated publications

Read individual records in context

The timeline combines selected references with a sample from the ingredient search. Dates use the index’s firstPublicationDate field; the PubMed record may distinguish an earlier online date from the print date. Written study notes appear alongside the records that have them. Other entries show the indexed bibliography and link to the paper.

Journal Article

PDE5A variation is associated with tadalafil response in men with diabetes mellitus and erectile dysfunction: a prospective proof-of-concept pharmacogenetic study.

Hostnik B, Janež A, Goričar K, Blagus T, Dolžan V, Klen J. The journal of sexual medicine. PMID 42407102.

This record identifies a publication and its indexed publication types. The full paper contains the study methods, population, formulation and results.

Read the PubMed record · Publisher record

Questions that shape the comparison

What route and schedule were actually tested? Were the other ingredients in the HealthRX.com blend also present in the study?

Source records

PDE5A variation is associated with tadalafil response in men with diabetes mellitus and erectile dysfunction: a prospective proof-of-concept pharmacogenetic study.Hostnik B, Janež A, Goričar K, Blagus T, Dolžan V, Klen J.The journal of sexual medicine. 2026-07-01. PMID 42407102. Journal Article.
Improved cardiac function and quality of life with initial macitentan-tadalafil combination therapy compared to tadalafil alone in pulmonary arterial hypertension.Chen Y, Kuang Y, Zhao Q.American journal of translational research. 2026-07-15. PMID 42630642. research-article, Journal Article.
Effects of tadalafil on endothelial, angiogenic, metabolic, and microRNA biomarker profiles in sexually active men with BPH and erectile dysfunction: a randomized controlled trial.Abomandour A, El-Shoura EAM, Fathi BA, Elewa HA, Abd-Eldayem AM, Zalat ZA.Naunyn-Schmiedeberg's archives of pharmacology. 2026-08-01. PMID 42538422. Journal Article.
QbD consideration for developing and validating the dissolution test method for quantitative analysis of tadalafil chewable tablets.Park SH, Kim JE.Journal of chromatographic science. 2026-08-01. PMID 42696759. Journal Article.
Neurovascular effects of tadalafil in patients with cerebral small vessel disease: ETLAS-2 substudy.Ölmestig J, Mortensen KN, Fagerlund B, Naveed N, Nordling MM, Christensen H, Iversen HK, Poulsen MB, Siebner HR, Kruuse C.Brain communications. 2026-08-13. PMID 42643719. Clinical Trial, research-article, Journal Article.
The role of the atherogenic index of plasma in response to once-daily tadalafil in men with erectile dysfunction.Gezmiş CT, Çilesiz NC, Uzut M, Satılmışoğlu M, Eroğlu A, Çetin B, Mert MS, Balcı MBC.The aging male : the official journal of the International Society for the Study of the Aging Male. 2026-09-21. PMID 42766789. Journal Article.

Research data assembled by HealthRX.com from the displayed source records, October 5, 2026. The atlas contains a dated literature search and selected studies; it is not an exhaustive systematic review.