Sexual health

Vardenafil: the research history.

Vardenafil is one of the four ingredients listed for TEMPO. Its individual research history needs to be read separately from the evidence for the complete sublingual formulation.

1,206records matching the ingredient search
1connected formulations
6displayed publication records

How the research connects to the formula

TEMPO also contains sildenafil, tadalafil and apomorphine. Its concentration field names the ingredients, but does not publish a numerical strength for each one. A literature comparison should leave those numerical fields unspecified rather than reconstructing them from another product.

The research map can connect the vardenafil record to the other ingredient histories. That connection is a way to inspect the formula, not a calculation of how much benefit the combination adds.

Current HealthRX.com formulation map
ProductListed formulationConnected ingredient research
TEMPO 4-in-1Apomorphine / Sildenafil / Tadalafil / VardenafilApomorphine · Sildenafil · Tadalafil · Vardenafil

Publication history

When the ingredient appeared in the literature

The chart counts records mentioning the search terms in their title or abstract. It includes research beyond sexual health. Use the period controls to inspect the count.

2026: 18 indexed publications. 2026 includes publications dated through October 5. The earlier bars cover longer periods than the annual bars.

View the chart as a data table
PeriodPublications
1900-19590
1960-19690
1970-19790
1980-19890
1990-19990
2000-2009546
2010-2014298
2015-2019165
202041
202137
202225
202326
202414
202536
202618
Search query and data source

Source: Europe PMC’s PubMed-indexed records. Retrieved October 5, 2026. The index’s firstPublicationDate field supplies the dates and chart periods; it can normalize a month-only record to the first day of the month. Dates through October 5 are included. Counts can change as the index adds or corrects records.

TITLE_ABS:(vardenafil) AND SRC:MED AND FIRST_PDATE:[1900-01-01 TO 2026-10-05]

Open this literature search · Download the data

A closer search for this product question

The focused search returns 684 publications. It narrows the ingredient query to terms connected with its catalog use. Its displayed records remain a search sample, not a ranking of study quality.

View the focused query

TITLE_ABS:(vardenafil) AND TITLE_ABS:("erectile dysfunction") AND SRC:MED AND FIRST_PDATE:[1900-01-01 TO 2026-10-05]

Open the focused search

Dated publications

Read individual records in context

The timeline combines selected references with a sample from the ingredient search. Dates use the index’s firstPublicationDate field; the PubMed record may distinguish an earlier online date from the print date. Written study notes appear alongside the records that have them. Other entries show the indexed bibliography and link to the paper.

review-article · Review · Journal Article

Vardenafil in the multidisciplinary management of erectile dysfunction: a narrative review on multidimensional outcomes and clinical integration.

Zhou J, Hu S, Ouyang Y, Kong Y, Liu M. World journal of urology. PMID 41973247.

This record identifies a publication and its indexed publication types. The full paper contains the study methods, population, formulation and results.

Read the PubMed record · Publisher record

Questions that shape the comparison

Did the study use vardenafil alone? Does it report an oral, sublingual or other route, and a numerical dose?

Source records

Vardenafil in the multidisciplinary management of erectile dysfunction: a narrative review on multidimensional outcomes and clinical integration.Zhou J, Hu S, Ouyang Y, Kong Y, Liu M.World journal of urology. 2026-04-13. PMID 41973247. review-article, Review, Journal Article.
Vardenafil Ameliorates Hypertension-Induced Erectile Dysfunction by Suppressing the HMGB1/RAGE/NF-κB Pathway.Zhao L, Wang K, Hua Q, Mao D, Ding H, Huang J, Sun J, Hua R.Urology. 2026-04-21. PMID 42025928. Journal Article.
Synergistic relaxation of ureteral smooth muscle by doxazosin and vardenafil: experimental implications for medical expulsive therapy.Uysal B, Tumer E, Kaplan E, Tore F, Eroglu M, Celikaslan H, Dokuyucu R.International urology and nephrology. 2026-05-04. PMID 42071078. Journal Article.
A comparative evaluation of on-demand phosphodiesterase-5 inhibitor efficacy in erectile dysfunction treatment: a systematic review and network meta-analysis of double-blind, placebo-controlled, randomized trials.Salonia A, Bettocchi C, Burnett A, Corona G, Fode M, Hassan T, Minhas S, Mulhall JP, Sadeghi-Nejad H, Vignesh SO, Wang R, Jannini EA.The journal of sexual medicine. 2026-06-01. PMID 42296271. Comparative Study, Systematic Review, Network Meta-Analysis, Journal Article.
Disarming Pseudomonas aeruginosa: repurposing vardenafil, valsartan, and olmesartan as anti-virulence and antibiofilm agents.Mahfouz AA, Abbas HA, Yousef N, Elgaml A.Scientific reports. 2026-08-07. PMID 42567869. Research Support, Non-U.S. Gov't, research-article, Journal Article.
Vardenafil efficacy for the treatment of persistent pulmonary hypertension of the newborn.El-Hindi S.World journal of clinical pediatrics. 2026-09-09. PMID 42626250. research-article, Journal Article.

Research data assembled by HealthRX.com from the displayed source records, October 5, 2026. The atlas contains a dated literature search and selected studies; it is not an exhaustive systematic review.