Pentoxifylline: Research History & Formulation Comparisons

How the research connects to the formula

The cream pairs pentoxifylline with aminophylline, ergoloid and sildenafil. The product’s formulation map can establish that ingredient relationship. It cannot convert a result from a different pentoxifylline regimen into a result for the cream.

In a useful comparison, the route is recorded before the study outcome. Oral research, laboratory experiments and topical combination research are separate kinds of evidence even when the same ingredient name appears in each.

Current HealthRX.com formulation map
Product	Listed formulation	Connected ingredient research
Prescription Arousal Cream	Aminophylline / Ergoloid / Pentoxifylline / Sildenafil	Aminophylline · Ergoloid · Pentoxifylline · Sildenafil

Publication history

When the ingredient appeared in the literature

The chart counts records mentioning the search terms in their title or abstract. It includes research beyond sexual health. Use the period controls to inspect the count.

2026: 91 indexed publications. 2026 includes publications dated through October 5. The earlier bars cover longer periods than the annual bars.

View the chart as a data table

Period	Publications
1900-1959	0
1960-1969	0
1970-1979	66
1980-1989	461
1990-1999	1442
2000-2009	1218
2010-2014	567
2015-2019	551
2020	123
2021	114
2022	120
2023	116
2024	108
2025	111
2026	91

Search query and data source

Source: Europe PMC’s PubMed-indexed records. Retrieved October 5, 2026. The index’s firstPublicationDate field supplies the dates and chart periods; it can normalize a month-only record to the first day of the month. Dates through October 5 are included. Counts can change as the index adds or corrects records.

TITLE_ABS:(pentoxifylline) AND SRC:MED AND FIRST_PDATE:[1900-01-01 TO 2026-10-05]

Open this literature search · Download the data

A closer search for this product question

The focused search returns 35 publications. It narrows the ingredient query to terms connected with its catalog use. Its displayed records remain a search sample, not a ranking of study quality.

View the focused query

TITLE_ABS:(pentoxifylline) AND TITLE_ABS:((sexual OR arousal OR "erectile dysfunction")) AND SRC:MED AND FIRST_PDATE:[1900-01-01 TO 2026-10-05]

Open the focused search

Dated publications

Read individual records in context

The timeline combines selected references with a sample from the ingredient search. Dates use the index’s firstPublicationDate field; the PubMed record may distinguish an earlier online date from the print date. Written study notes appear alongside the records that have them. Other entries show the indexed bibliography and link to the paper.

Comparative Study · Randomized Controlled Trial · Journal Article

Phoenix dactylifera L. pollen versus pentoxifylline on improvement of sperm parameters in idiopathic male infertility: A randomized clinical trial.

Mirzaei M, Asbagh FA, Safavi M, Yekaninejad MS, Rahimi R, Pourmand G, Karimi M, Farshbaf-Khalili A, Sarrafi S. Journal of ethnopharmacology. PMID 38604508.

This record identifies a publication and its indexed publication types. The full paper contains the study methods, population, formulation and results.

Read the PubMed record · Publisher record

Questions that shape the comparison

Was pentoxifylline administered topically or by another route? What comparison group and endpoint did the study use?

Source records

Phoenix dactylifera L. pollen versus pentoxifylline on improvement of sperm parameters in idiopathic male infertility: A randomized clinical trial.Mirzaei M, Asbagh FA, Safavi M, Yekaninejad MS, Rahimi R, Pourmand G, Karimi M, Farshbaf-Khalili A, Sarrafi S.Journal of ethnopharmacology. 2024-04-10. PMID 38604508. Comparative Study, Randomized Controlled Trial, Journal Article.

Impact of the Advent of Collagenase Clostridium histolyticum on the Surgical Management of Peyronie's Disease: A Population-Based Analysis.Bal KS, Achalu P, Okene MO, Krug A, Hsieh TC, Mirheydar H.The Permanente journal. 2024-12-06. PMID 39639714. research-article, Journal Article.

Investigating the Relationship Between Psoriatic Arthritis and Peyronie's Disease: A Case Study Analysis.Evans MJ, Schmidt VJ, Kossman B, Hafer D, King C.Cureus. 2026-04-13. PMID 42137679. Journal Article, Case Reports, case-report.

Pentoxifylline in children with acute encephalitis syndrome: a randomized control trial.S YK, Dwibedi B, Das RR.European journal of pediatrics. 2026-05-27. PMID 42201544. Randomized Controlled Trial, Journal Article.

Effectiveness of Pentoxifylline in Adult Patients with COVID-19: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Saghafi F, Heydari B, Motevali Haghighi S, Salehi-Abargouei A, Hoseini SM, Akrami A, Sahebnasagh A.Current medicinal chemistry. 2026-08-10. PMID 42634361. Meta-Analysis, Journal Article.

Retraction Note: Pentoxifylline alleviates vascular impairment in insulin resistance via TNF-α inhibition.El-Bassossy HM, El-Moselhy MA, Mahmoud MF.Naunyn-Schmiedeberg's archives of pharmacology. 2026-08-21. PMID 42624931. Journal Article, Retraction Notice.

The adverse effects of testicular hyperthermia on semen quality in stallions are attenuated by oral pentoxifylline treatment.Sancler-Silva YFR, Ball BA, Silva-Junior ER, Freitas-Dell'aqua CP, Esteller-Vico A, El-Sheikh Ali H, Boakari YL, Freitas MS, Papa FO.Journal of equine veterinary science. 2026-08-24. PMID 42637109. Journal Article.

Preliminary in vitro effects of trehalose, pentoxifylline and MitoTEMPO on post-thaw quality of ram semen.Öztürk C, Bodu M, Öztürk AE, Bucak MN, Aksoy NH, Arslan R, Ataman MB.Acta veterinaria Scandinavica. 2026-09-04. PMID 42786521. research-article, Journal Article.

Research data assembled by HealthRX.com from the displayed source records, October 5, 2026. The atlas contains a dated literature search and selected studies; it is not an exhaustive systematic review.